Sunday, 22 September 2019

Which Sort of Learner Are You?

Did you know that there are different ways of learning? So which suits you best?

29% of people are visual learners: they learn by looking.
34% of people are auditory learners: they learn by listening.
37% of people are kinesthetic learners: they learn by doing.

Visual learners
  • Times table: cover over it and picture it.
  • Spelling a word: imagine what it looks like.
  • Learning a foreign language: looking at a picture next to the word.
  • Learning a history fact: watch a video.
  • Learning how something works: look at a diagram or a picture.
  • Learning a story: imagine the story.
  • Learning a new sport: watch a demonstration.
  • Learning how to make a cake: look at instructions on the packet or recipe.
  • Learning to count in a foreign language: look at cards/posters.
  • Learning how the eye works: look at a diagram of the eye.
  • Learning how to use a new tool: watch someone else use it.
Auditory learners
  • Times table: say it out loud.
  • Spelling a word: say each letter out loud.
  • Learning a foreign language: repeating it out loud to yourself.
  • Learning a history fact: listen to a person on the radio explaining what happened.
  • Learning how something works: listen to someone telling you how it works.
  • Learning a story: tell someone else the story.
  • Learning a new sport: repeat back instructions to the coach.
  • Learning how to make a cake: listen to a tape about what to do.
  • Learning to count in a foreign language: sing the words.
  • Learning how the eye works: listen to someone telling you.
  • Learning how to use a new tool: listen to someone telling you.
Kinesthetic learners
  • Times table: adding on fingers.
  • Spelling a word: write it down.
  • Learning a foreign language: writing it out over and over again.
  • Learning a history fact: role play - act out what happened.
  • Learning how something works: take the object apart and try to put it back together.
  • Learning a story: draw pictures/cartoons to tell the story.
  • Learning a new sport: do it.
  • Learning how to make a cake: try to make it.
  • Learning to count in a foreign language: play French bingo.
  • Learning how the eye works: make a model.
  • Learning how to use a new tool: teach someone else how to use it.
'On task' times
  • Adults: 20 to 25 mins with 2 to 5 min breaks between.
  • 10 years: 12 mins focus time, then 2 to 5 mins review or play in between.
  • 6 years: 6 mins focus time, then 2 to 3 mins review or play in between.
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Sunday, 15 September 2019

Good Buys to Avoid Waste

In 2018, two sisters challenged each other to see which of them could reduce their waste the most. Here are the ways they found useful.
  • Mesh grocery bags for fruit and veg (but berries are usually in plastic containers).
  • Swap hand wash and shower gel in bottles for soap bars.
  • Stainless steel straws.
  • Ditch clingfilm and use re-usable beeswax wrap (made from cotton coated in beeswax and oil) to cover leftovers.
  • Switch to loose leaf tea (most tea bags contain a plastic called polypropylene). 
  • Instead of using detergent, buy an Ecoegg, a hollow 'egg' filled with natural cleaning pellets, that you put in the drum with your clothes.
  • Or try Splosh powder sachets that dissolve in water to make detergent.
  • For toilet paper, Who Gives a C***, delivers recycled, paper-wrapped rolls to the door.
  • Morrisons online supermarket recycles bags (the driver takes them back) and offer a 'wonky veg box' containing seasonal produce.
  • Aldi's own brand dishwasher tablets are plastic free.
  • It's worth taking a Tupperware container to the butcher's counter in supermarkets - ask nicely and they will put your purchases in the container.
  • Try bubble bath lolly sticks from Lush, which are packaged in water-soluble starch chips.
  • A British company Wyatt and Jack recycles broken paddling pools and beach inflatables into beautiful bags.
  • Conkers can be turned into washing detergent by chopping and soaking them in water. It works.
  • New baby? Try washable cloth nappies or Naty nappies made of soft, plant-based material. And use re-usable baby wipes (one brand is Cheeky Wipes).
  • Tesco, M&S and Oxfam sell Christmas cards in boxes instead of plastic wraps.
  • Crisps - British brand Two Farmers uses compostable packaging.
  • Bamboo coffee cups.
  • It is possible to make bin liners from old newspapers - look for online videos.
Source: Sisters who went to war on plastic, Daily Mail, 4 Feb. 2019

Sunday, 8 September 2019

How Society Overlooks Women

How society overlooks women
Points raised in Invisible Women: Exposing Data Bias In A World Designed For Men by Caroline Criado Perez, published by Chatto and Windus, 2019.
*****
Everyday women struggle to use products, software and spaces that have been designed by men, for men. They fail to take into account women’s typically smaller size and different needs. While not generally malicious or even deliberate, this can even be fatal in a car crash or medical treatment. This comes from assuming that a male viewpoint is the ‘default’, while half the global population (women) are a niche interest.
It all starts with education.
A study of US school history textbooks from 1960 to 1990 found only 9 per cent of names were female. A 2017 analysis of political science textbooks found only 10.8 per cent of pages referenced women. And in language example sentences, men outnumber women three to one, according to 30 years of Western studies.
The result? Girls starting primary school aged five are as likely to think women can be ‘really, really smart’ but by age six they no longer think this is true. And a 2016 study found male students consistently ranked fellow men as more intelligent than better-performing women.
One size fits all …men.
Product design focuses on men. Smartphone screens are typically around 5.5 in, so the average man can use it one handed – but the average woman can’t. (But women are more likely to buy a smartphone.) [Blogger note: smartphone design for women tends to focus on looks (colour of case) than function.]
The first emojis were intended to be gender neutral, but looked like men. When women complained, they designed a separate set: male runner and female runner.
Most pianos are made with a standard keyboard octave of 7.4 in. The average male handspan of 8.9 in but the average of women is 7.9 in when fully stretched. In addition, this results in a 50% higher risk of pain and injury for women pianists. A smaller piano does exist, and numerous studies confirm it’s better for players’ health and musical ability, but there remains a real reluctance in the music world to adapt.
Whose safety comes first?
Women are 47% more likely to be seriously injured in a car crash than men, and 17% more likely to die. Why? Women are usually shorter, so tend to sit further forward when driving in order to reach the pedals and see out. Car makers say this increases the risk of internal injury as it is not the ‘standard seating position’ – which is determined by the fact that crash test dummies are typically 1.77m tall and 76 kg, with male muscle mass and a male spinal column (women’s vertebrae are spaced differently, among other things). While there is now a single European regulatory test that uses a ‘female’ dummy — but it’s only tested in the passenger seat and is really just a scaled-down male dummy.
Right tools for the job
A 2017 study of emergency workers found that 95 per cent of women said their protective gear interfered with their work, as the gear is largely designed for men. Stab vests ride up leaving the abdomen unprotected, and body armour is removed in order to use equipment; this leaves women more vulnerable to injury and death.
While serious injuries at work have long been decreasing for men, there is evidence that they have been increasing among women, but we know little about effects on women. Dust disease in miners is well researched, but exposures in ‘women’s’ work is not. Toxins affect women differently to men: women tend to be smaller, with thinner skin, lowering the levels with which they can safely cope, and also have more body fat in which chemicals can accumulate. Women are often left out of studies in industries where men and women work together, as including both might muddle the data. And in most female-dominated industries (such as nail salons, where workers use a toxic cocktail of chemicals with known links to cancer, miscarriage and lung disease), an incredibly small number of studies have ever been done.
Why drugs don’t work
For millennia, medicine has assumed that male bodies are the default [Blogger: actually the female is biologically the default human.] so there is a huge data gap with regard to women’s health. Women are very often excluded from clinical trials, and medical students learn about women’s bodies and health as an ‘extra’, not the norm.
There are big differences between male and female physiology. Using male mice for one study, and female mice for another on the same topic gave the opposite result. Which is why, from blood pressure pills to aspirin, many drugs just don’t work as well for women. U.S. data on ‘adverse drug reactions’ from 2004 to 2013 shows women suffered 2 million bad reactions, compared to 1.3 million for men. The second most common ‘adverse reaction’ for women, after nausea, was that the drug simply didn’t work at all.
Although some groups of women are now more likely than men to have a heart attack, they often have different symptoms — only one in eight women experience chest pain, for example. A US study found that the ‘risk prediction strategies’ used in many hospitals are based on two-thirds male patients, meaning women’s ‘atypical’ heart attacks are often missed.
Of around 50 drugs for heart failure, some just aren’t safe for half the population. One, used to break up blood clots, can cause ‘significant bleeding problems in women’.
And we may be missing drugs which would work for women. Period pain affects up to 90 per cent of women, but there is little available to help. While a 2013 study appeared to have found a cure, it ran out of funding before it could prove its primary hypothesis, which suggested that sildenafil citrate could give four hours of ‘total pain relief’ without apparent side-effects. No further funding has been forthcoming.
Yet sildenafil citrate is no new drug — it’s the medical name for Viagra. Tested in the Nineties, it didn’t work as a heart medication, but the all-male study participants reported an increase in erections, and so it was rushed to market for erectile dysfunction. A happy ending for men. But what if that first trial included women? Might we have had an effective drug for period pain for decades?
Staying (too) cool in the office
Modern workplaces often have doors too heavy for women to open easily, and glass stairs and lobby floors mean anyone can see up your skirt.
The standard office temperature was determined in the Sixties based on the metabolic resting rate of the average 40-year-old, 70kg man. But a recent study found that ‘the metabolic rate of young adult females performing light office work is significantly lower’ than men’s. The standard formula may overestimate female metabolic rate by as much as 35 per cent, meaning current offices are on average five degrees too cold for women.
Falling on deaf ears
Virtual reality headsets fall off the average woman’s head, and augmented reality glasses have lenses too far apart for a woman to focus on the image. Apple’s much-hyped health tracker app failed to build in the most basic of female needs — a monthly period tracker.
Female business owners receive less than half the investment of their male counterparts, but generate twice as much revenue.
Voice-recognition software is often hopelessly male-biased. One study found Google’s was 70 per cent more likely to recognise male speech. Some helpful experts have suggested women have ‘lengthy training’ to fix the ‘many issues’ with their voices!! The problem is that speech recognition technology is trained on large databases of voice recordings — which appear dominated by men (the data used is confidential, but the results speak for themselves).
When women are under or misrepresented in data, it can play havoc with modern technology. Programs which are trained to associate images and terms with qualities can end up with gender bias. So a male programmer’s website could be judged more relevant than that of a female programmer, potentially meaning the woman would not be considered for a job.
Sources
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Sunday, 1 September 2019

What Do We Know About Cancer?

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells.

Human lifespan has increased substantially over time. Infectious diseases kept life expectancy very low for a long time. While we are now able to treat many diseases, and prevent others through immunisation, cancer remains a problem. Early diagnosis can help, but finding effective treatments has been difficult.

1775 A London surgeon, Percival Potts had noticed a sharp rise in open, festering scrotal sores in chimney boys, which he attributed to soot; the first documentation of an external agent causing cancer.

1855  Rudolf Virchow was the first to link the origin of cancer with otherwise normal cells.

1870s Walther Fleming uses a blue dye to stain cells, which shows up the internal structure of cells. This revealed the threadlike objects he named chromosomes.

1890s David Paul von Hansemann tried the dye on cancer cells. He noted that the chromosomes of cancer cells were bent, broken and duplicated.

1910 Peyton Rous proved that solid tumours can be caused by a virus.

1924 Otto Warburg saw that while most diseases are specific (tuberculosis is a respiratory disease, cancer has multiple causes, and could arise in any body tissue. He observed that cancer cells generate energy in a different way to healthy cells.

Animal (including humans) cells contain several structures, such as nucleus, chromosomes and mitochondria, Typically each cell has 1,000 to 2,000 mitochondria, which generate energy which allows a body to function. Early forms of life came into existence in an atmosphere with no oxygen, so used a fermentation pathway (anaerobic respiration) to generate energy. It still exists in living things from bacteria to animals, birds and humans, but this pathway is very inefficient taking 18 times more glucose to extract the same amount than from aerobic respiration. As life forms evolved, aerobic respiration took over. A normal human cell typically obtains almost 90% of its energy through aerobic respiration, and the rest through an anaerobic pathway. Certain cells (e.g. muscle cells) can create energy without oxygen by generating lactic acid, but only briefly, when oxygen is absent or muscles demand great amounts of energy. Once oxygen becomes available or the activity stops, cells resume using aerobic respiration.

Damaged mitochondria can no longer use aerobic respiration, even in the presence of oxygen, so signal to the nucleus, which then switches on the anaerobic pathway known as fermentation. This then changes the cell behaviour leading to uncontrolled proliferation, genetic mutations and evasion of cell death. Warburg also noted that normal, healthy cells deprived of oxygen for brief periods of time (hours) turned cancerous and could not revert to aerobic respiration in the presence of oxygen.

1953 James Watson and Francis Crick published a paper on the structure of DNA. The results were based partly on fundamental studies by Rosalind Franklin, Raymond Gosling and Maurice Wilkins. Research then focused on genetic abnormalities as the likely cause of cancer.

1970s Harold Varmous and Michael Bishop isolated the src gene in a known cancer causing virus (Rous sarcoma virus). They then found the src gene in each animal they tested (fish, rabbits, mice, cows, sheep and humans. The viral, cancer causing gene was only a subtly different from the normal version, and in fact a distorted copy of a gene common to all species and part of our inherited DNA. research then focused on what altered the gene.

1943-1946 Nitrogen mustard was found to significantly reduce the size of lymphoid tumours in mice, and then in humans. While the remissions proved to be brief and incomplete, this line of research led to the discovery of other chemotherapy drugs. However, the treatments attacked their immune systems and caused debilitating nausea, and cancers would often return.

1970s Pete Pederson (following Warburg's lead)  found that cancer cells had a reduced ability to respire, and they showed various structural abnormalities. In 1977 Pederson and Ernesto Bustamante found a single molecular alteration in the cell that is responsible for the increased fermentation.

1980s Research into identifying cancer causing genes (many have been found but also that some cancer cells had no mutations) and further drugs to combat cancer.

1988 A small reduction in cancer rates was due to (a) anti-smoking campaigns and (b) improved early detection.

2000 onward. Further interest in mitochondrial function but the scientific community is divided. Thomas Seyfried found that reducing calorie intake in mice with tumours began to slow the tumour growth and then tied this up with research on mitochondria.

Currently treatment is still often ineffective, especially in advanced metastatic cancer and brain cancer. Also current therapies may increase survival on average for just a few months, and at the same time promote tumour agressiveness and spread in some cancers.

DNA. The double helix of DNA is made up from four molecules: adenine, guanine, thymine and cytosine (AGTC). The operations of a cell are carried out by proteins, which act as gateways and facilitate chemical reactions that generate energy and power and receive signals from hormones or nutrients. In some sections, DNA directs proteins to "stay away" allowing specific sections to be expressed or hidden. This varies with the type of cell: in a hair follicle the gene encoding for hair protein is exposed but in a liver cell is is wrapped up.

The brain consumes 20 per cent of the energy we consume at any given time.While other tissues can transition to burning fatty acids, brain cells can only burn glucose. When food is scarce brain cells can use ketone bodies for fuel. More than any other mammal, humans are efficient at survival. Ketone bodies allow a normal weight human to go from two to three weeks without food to about two months. Some scientists think that humans evolved to exist in ketosis from time to time.

Reference
Tripping over the Truth by Travis Christofferson. Chelsea Green Publishing, 2017

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